Mouse Fbxo3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxo3
Locus ID	57443
Kit Components	GA206194G1, Fbxo3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206194G2, Fbxo3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206194G3, Fbxo3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_020593, NM_212433, NR_149726, NM_001355504, NM_001355505, NM_001355506, NM_001355507
Synonyms	1200002G09Rik; 1700026K02Rik; AI046358; Fba
Summary	Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).[UniProtKB/Swiss-Prot Function]

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