Mouse Pus1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pus1
Locus ID	56361
Kit Components	GA205922G1, Pus1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205922G2, Pus1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205922G3, Pus1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001025561, NM_001025562, NM_001347390, NM_019700, NM_001359218, NM_001359219
Synonyms	A730013B20Rik; MPUS1; mPus1p
Summary	Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:10094309). Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (PubMed:15327771). Isoforms 3 and 4 do not form pseudouridine when expressed in vitro (PubMed:11085940).[UniProtKB/Swiss-Prot Function]

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