Mouse Dkk3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dkk3
Locus ID	50781
Kit Components	GA205361G1, Dkk3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205361G2, Dkk3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205361G3, Dkk3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_015814, NM_001360257, NM_001360260, NM_001360261
Synonyms	AW061014; C87148
Summary	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).[UniProtKB/Swiss-Prot Function]

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