Mouse E2f6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	E2f6
Locus ID	50496
Kit Components	GA205316G1, E2f6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205316G2, E2f6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205316G3, E2f6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_033270, NR_027677
Synonyms	AI462434; E2F6a; E2F6b; EMA
Summary	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity).[UniProtKB/Swiss-Prot Function]

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