Mouse Ikzf4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ikzf4
Locus ID	22781
Kit Components	GA204745G1, Ikzf4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204745G2, Ikzf4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204745G3, Ikzf4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011772, NM_001358536, NM_001358537
Synonyms	A630026H08Rik; Eos; Zfpn1a4; Znfn1a4
Summary	DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (PubMed:19696312).[UniProtKB/Swiss-Prot Function]

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