Mouse Ube2i activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ube2i
Locus ID	22196
Kit Components	GA204517G1, Ube2i gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204517G2, Ube2i gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204517G3, Ube2i gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177609, NM_001177610, NM_011665, NM_001357694
Synonyms	5830467E05Rik; F830028O17Rik; UBC9; Ubce2i; Ubce9
Summary	Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'.[UniProtKB/Swiss-Prot Function]

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