Mouse Ube2m activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ube2m
Locus ID	22192
Kit Components	GA204515G1, Ube2m gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204515G2, Ube2m gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204515G3, Ube2m gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001168469, NM_001243968, NM_145578
Synonyms	2510040H03Rik; Ubc-rs2; UBC12
Summary	Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity).[UniProtKB/Swiss-Prot Function]

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