Mouse Trpc4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Trpc4
Locus ID	22066
Kit Components	GA204455G1, Trpc4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204455G2, Trpc4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204455G3, Trpc4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001253682, NM_001253683, NM_016984, NR_046161
Synonyms	CCE1; STRPC4; Trp4; Trrp4
Summary	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells.[UniProtKB/Swiss-Prot Function]

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