Mouse Tcf4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tcf4
Locus ID	21413
Kit Components	GA204239G1, Tcf4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204239G2, Tcf4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204239G3, Tcf4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001083967, NM_013685, NM_001361126, NM_001361127, NM_001361128, NM_001361129
Synonyms	5730422P05Rik; ASP-I2; bHLHb19; E2-2; E2.2; ITF-2; ITF-2b; ITF2; ME2; MITF-2A; MITF-2B; SEF-2; SEF2
Summary	Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Isoform 2 inhibits MYOD1 activation of the cardiac alpha-actin promoter. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. May have a regulatory function in developmental processes as well as during neuronal plasticity.[UniProtKB/Swiss-Prot Function]

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