Mouse Scn8a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scn8a
Locus ID	20273
Kit Components	GA203785G1, Scn8a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203785G2, Scn8a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203785G3, Scn8a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001077499, NM_011323
Synonyms	AI853486; C630029C19Rik; dmu; med; mnd-2; mnd2; NaCh6; Nav1.6; nmf2; nmf58; nmf335; nur14; seal
Summary	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages, isoform 5 may participate in the control of podosome and invadopodia formation.[UniProtKB/Swiss-Prot Function]

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