Mouse Scn1a activation kit by CRISPRa
CAT#: GA203780
Scn1a CRISPRa kit - CRISPR gene activation of mouse sodium channel, voltage-gated, type I, alpha
CNY 12,255.00
货期*
4周
规格
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Scn1a |
Locus ID | 20265 |
Kit Components | GA203780G1, Scn1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203780G2, Scn1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203780G3, Scn1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001313997, NM_018733 |
Synonyms | B230332M13; Nav1.1 |
Summary | Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
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