Mouse Rab12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rab12
Locus ID	19328
Kit Components	GA203524G1, Rab12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203524G2, Rab12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203524G3, Rab12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_024448
Synonyms	2900054P15Rik; AW555448; C77700
Summary	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.[UniProtKB/Swiss-Prot Function]

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