Mouse Cyth1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cyth1
Locus ID	19157
Kit Components	GA203419G1, Cyth1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203419G2, Cyth1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203419G3, Cyth1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001112699, NM_001112700, NM_011180
Synonyms	CLM1; CTH-1; CYTIP; Pscd1
Summary	Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6 (PubMed:18042453, PubMed:20080746). Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity (PubMed:20080746, PubMed:29420262).[UniProtKB/Swiss-Prot Function]

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