Mouse Penk activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Penk
Locus ID	18619
Kit Components	GA203174G1, Penk gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203174G2, Penk gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203174G3, Penk gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001002927, NM_001348209
Synonyms	AI326464; ENK; Penk1; PPA
Summary	Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.[UniProtKB/Swiss-Prot Function]

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