Mouse Notch3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Notch3
Locus ID	18131
Kit Components	GA202938G1, Notch3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202938G2, Notch3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202938G3, Notch3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008716
Synonyms	AW229011; hpbk; N3
Summary	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development.[UniProtKB/Swiss-Prot Function]

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