Mouse Mgrn1 activation kit by CRISPRa
CAT#: GA202617
Mgrn1 CRISPRa kit - CRISPR gene activation of mouse mahogunin, ring finger 1
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Mgrn1 |
Locus ID | 17237 |
Kit Components | GA202617G1, Mgrn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202617G2, Mgrn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202617G3, Mgrn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001252437, NM_029657, NM_001357061, NM_001357062 |
Synonyms | 2610042J20Rik; md; mKIAA0544; nc |
Summary | E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Acts also as a negative regulator of hedgehog signaling (PubMed:29290584).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN510070 | Mgrn1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |