Mouse Smad3 activation kit by CRISPRa
CAT#: GA202546
Smad3 CRISPRa kit - CRISPR gene activation of mouse SMAD family member 3
CN¥ 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Smad3 |
Locus ID | 17127 |
Kit Components | GA202546G1, Smad3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202546G2, Smad3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202546G3, Smad3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_016769 |
Synonyms | AU022421; Madh3 |
Summary | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
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KN316272 | Smad3 - mouse gene knockout kit via CRISPR, HDR mediated |
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KN316272BN | Smad3 - mouse gene knockout kit via CRISPR, HDR mediated |
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KN316272LP | Smad3 - mouse gene knockout kit via CRISPR, HDR mediated |
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KN316272RB | Smad3 - mouse gene knockout kit via CRISPR, HDR mediated |
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