Mouse Ksr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ksr1
Locus ID	16706
Kit Components	GA202392G1, Ksr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202392G2, Ksr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202392G3, Ksr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001348207, NM_013571
Synonyms	AW492498; B-KSR1; D11Bhm183e; D11Bhm184e; hb; Ksr; mKSR1; RSU2
Summary	Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438). Does not have kinase activity by itself (Probable).[UniProtKB/Swiss-Prot Function]

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