Mouse Kcnn4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kcnn4
Locus ID	16534
Kit Components	GA202283G1, Kcnn4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202283G2, Kcnn4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202283G3, Kcnn4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163510, NM_008433
Synonyms	IK1; IKCA1; KCa3.1; KCA4; mIKCa1; SK4; SKCas
Summary	Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:9705284). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:20884616). Plays a role in the late stages of EGF-induced macropinocytosis (By similarity).[UniProtKB/Swiss-Prot Function]

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