Mouse Itpr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Itpr1
Locus ID	16438
Kit Components	GA202223G1, Itpr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202223G2, Itpr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202223G3, Itpr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010585
Synonyms	D6Pas2; ENSMUSG00000072853; Gm10429; InsP3R; insP3R1; Ip3r; IP3R 1; IP3R1; Itpr-1; opt; P400
Summary	Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.[UniProtKB/Swiss-Prot Function]

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