Mouse Itpr1 activation kit by CRISPRa
CAT#: GA202223
Itpr1 CRISPRa kit - CRISPR gene activation of mouse inositol 1,4,5-trisphosphate receptor 1
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Itpr1 |
Locus ID | 16438 |
Kit Components | GA202223G1, Itpr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202223G2, Itpr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202223G3, Itpr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_010585 |
Synonyms | D6Pas2; ENSMUSG00000072853; Gm10429; InsP3R; insP3R1; Ip3r; IP3R 1; IP3R1; Itpr-1; opt; P400 |
Summary | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN508517 | Itpr1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |