Mouse Insr activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Insr
Locus ID	16337
Kit Components	GA202177G1, Insr gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202177G2, Insr gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202177G3, Insr gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010568
Synonyms	4932439J01Rik; CD220; D630014A15Rik; IR; IR-A; IR-B
Summary	This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]

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