Mouse Il18r1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il18r1
Locus ID	16182
Kit Components	GA202139G1, Il18r1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202139G2, Il18r1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202139G3, Il18r1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001161842, NM_001161843, NM_008365
Synonyms	Il1rrp; Il18ralpha
Summary	Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046).[UniProtKB/Swiss-Prot Function]

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