Mouse Ikbkg activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ikbkg
Locus ID	16151
Kit Components	GA202111G1, Ikbkg gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202111G2, Ikbkg gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202111G3, Ikbkg gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001136067, NM_001161421, NM_001161422, NM_001161423, NM_001161424, NM_010547, NM_178590
Synonyms	1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO
Summary	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.[UniProtKB/Swiss-Prot Function]

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