Mouse Hrh1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hrh1
Locus ID	15465
Kit Components	GA201988G1, Hrh1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201988G2, Hrh1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201988G3, Hrh1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001252642, NM_001252643, NM_001317124, NM_001317125, NM_001317126, NM_008285
Synonyms	Bphs; H1R; HH1R; Hir
Summary	In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.[UniProtKB/Swiss-Prot Function]

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