Mouse Gnb5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gnb5
Locus ID	14697
Kit Components	GA201663G1, Gnb5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201663G2, Gnb5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201663G3, Gnb5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_010313, NM_138719, NR_073186
Synonyms	flr; Gbeta5; GBS
Summary	Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).[UniProtKB/Swiss-Prot Function]

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