Mouse Frk activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Frk
Locus ID	14302
Kit Components	GA201475G1, Frk gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201475G2, Frk gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201475G3, Frk gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159544, NM_010237, NM_001358769
Synonyms	BSK; BSK/IYK; C85044; GTK; RAK
Summary	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).[UniProtKB/Swiss-Prot Function]

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