Mouse Frk activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Frk
Locus ID	14302
Kit Components	GA201475G1, Frk gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201475G2, Frk gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201475G3, Frk gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001159544, NM_010237, NM_001358769
Synonyms	BSK; BSK/IYK; C85044; GTK; RAK
Summary	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).[UniProtKB/Swiss-Prot Function]

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