Mouse Fgfr3 activation kit by CRISPRa

CAT#: GA201411

Fgfr3 CRISPRa kit - CRISPR gene activation of mouse fibroblast growth factor receptor 3



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CN¥ 12,255.00


货期*
4周

规格
    • 1 kit

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Fgfr3
Locus ID 14184
Kit Components

GA201411G1, Fgfr3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA201411G2, Fgfr3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA201411G3, Fgfr3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Reference Data
RefSeq NM_001163215, NM_001163216, NM_001163217, NM_001205270, NM_008010
Synonyms CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3; sam3
Summary This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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