Mouse Phc1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Phc1
Locus ID	13619
Kit Components	GA201183G1, Phc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201183G2, Phc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201183G3, Phc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001042623, NM_001271579, NM_007905, NR_073364, NM_001355215
Synonyms	AW557034; Edr; Edr1; Mph1; Rae-28; rae28
Summary	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity).[UniProtKB/Swiss-Prot Function]

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