Mouse Phc1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Phc1
Locus ID	13619
Kit Components	GA201183G1, Phc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201183G2, Phc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201183G3, Phc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042623, NM_001271579, NM_007905, NR_073364, NM_001355215
Synonyms	AW557034; Edr; Edr1; Mph1; Rae-28; rae28
Summary	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity).[UniProtKB/Swiss-Prot Function]

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