Mouse Dok1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dok1
Locus ID	13448
Kit Components	GA201115G1, Dok1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201115G2, Dok1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201115G3, Dok1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001291799, NM_010070
Synonyms	AW557123; p62DOK
Summary	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).[UniProtKB/Swiss-Prot Function]

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