Mouse Dcn activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dcn
Locus ID	13179
Kit Components	GA201031G1, Dcn gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201031G2, Dcn gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201031G3, Dcn gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001190451, NM_007833
Synonyms	DC; DSPG2; PG40; PGII; PGS2; SLRR1B
Summary	This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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