Mouse Comt activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Comt
Locus ID	12846
Kit Components	GA200832G1, Comt gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200832G2, Comt gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200832G3, Comt gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001111062, NM_001111063, NM_007744
Synonyms	Comt1; D16Wsu103e; D330014B15Rik
Summary	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[UniProtKB/Swiss-Prot Function]

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