Mouse Cflar activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cflar
Locus ID	12633
Kit Components	GA200707G1, Cflar gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200707G2, Cflar gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200707G3, Cflar gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001289704, NM_001293804, NM_001293805, NM_009805, NM_207653, NR_110361, NM_001355056, NR_149255, NR_149256, NR_149257, NR_149258
Synonyms	2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip
Summary	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity).[UniProtKB/Swiss-Prot Function]

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