Mouse Agtrap activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Agtrap
Locus ID	11610
Kit Components	GA200129G1, Agtrap gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200129G2, Agtrap gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200129G3, Agtrap gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301281, NM_009642
Synonyms	3300002E14Rik; AT1R; Atrap; D4Wsu124e
Summary	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.[UniProtKB/Swiss-Prot Function]

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