Human GFRAL activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GFRAL
Locus ID	389400
Kit Components	GA118053G1, GFRAL gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA118053G2, GFRAL gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA118053G3, GFRAL gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_207410
Synonyms	bA360D14.1; C6orf144; GRAL; UNQ9356
Summary	Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]

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