Human STING (TMEM173) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	STING1
Locus ID	340061
Kit Components	GA117456G1, STING gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117456G2, STING gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117456G3, STING gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301738, NM_198282, NM_001367258
Synonyms	ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING
Summary	This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

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