Human KCTD1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KCTD1
Locus ID	284252
Kit Components	GA117108G1, KCTD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117108G2, KCTD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117108G3, KCTD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001136205, NM_001142730, NM_001258221, NM_001258222, NM_198991, NM_001351443
Synonyms	C18orf5; SENS
Summary	This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]

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