Human SIAH3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SIAH3
Locus ID	283514
Kit Components	GA117034G1, SIAH3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117034G2, SIAH3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117034G3, SIAH3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_198849
Synonyms	FLJ39203
Summary	Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.[UniProtKB/Swiss-Prot Function]

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