Human CNO6L (CNOT6L) activation kit by CRISPRa
CAT#: GA116718
CNOT6L CRISPRa kit - CRISPR gene activation of human CCR4-NOT transcription complex subunit 6 like
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CNOT6L |
Locus ID | 246175 |
Kit Components | GA116718G1, CNO6L gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116718G2, CNO6L gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116718G3, CNO6L gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001286790, NM_144571, NM_001365007, NM_001365006 |
Synonyms | CCR4b |
Summary | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3' UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN419766 | CNOT6L - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |