Human SPDYA activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPDYA
Locus ID	245711
Kit Components	GA116694G1, SPDYA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116694G2, SPDYA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116694G3, SPDYA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001008779, NM_001142634, NM_182756
Synonyms	RINGO3; RINGOA; SPDY1; SPY1
Summary	Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).[UniProtKB/Swiss-Prot Function]

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