Human USP12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	USP12
Locus ID	219333
Kit Components	GA116474G1, USP12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116474G2, USP12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116474G3, USP12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_182488
Synonyms	UBH1; USP12L1
Summary	Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).[UniProtKB/Swiss-Prot Function]

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