Human Synaptopodin 2 (SYNPO2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SYNPO2
Locus ID	171024
Kit Components	GA116236G1, Synaptopodin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116236G2, Synaptopodin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116236G3, Synaptopodin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001128933, NM_001128934, NM_001286754, NM_001286755, NM_133477
Synonyms	DKFZp686G051
Summary	Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).[UniProtKB/Swiss-Prot Function]

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