Human USP51 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	USP51
Locus ID	158880
Kit Components	GA115980G1, USP51 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115980G2, USP51 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115980G3, USP51 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_201286
Synonyms	deubiquitinating enzyme 51; ubiquitin-specific processing protease 51; ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51; ubiquitin specific protease 51; ubiquitin thiolesterase 51
Summary	Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).[UniProtKB/Swiss-Prot Function]

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