Human SAMD8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SAMD8
Locus ID	142891
Kit Components	GA115445G1, SAMD8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115445G2, SAMD8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115445G3, SAMD8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001174156, NM_144660
Synonyms	HEL-177; SMSr
Summary	Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.[UniProtKB/Swiss-Prot Function]

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