Human SUHW2 (ZNF280B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZNF280B
Locus ID	140883
Kit Components	GA115427G1, SUHW2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115427G2, SUHW2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115427G3, SUHW2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_080764, NR_130642, NR_130643
Synonyms	5 OY11.1; D87009.C22.3; SUHW2; ZNF279; ZNF632
Summary	The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

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