Human Plexin A4 (PLXNA4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLXNA4
Locus ID	91584
Kit Components	GA114127G1, Plexin A4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114127G2, Plexin A4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114127G3, Plexin A4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001105543, NM_020911, NM_181775
Synonyms	FAYV2820; PLEXA4; PLXNA4A; PLXNA4B; PRO34003
Summary	Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).[UniProtKB/Swiss-Prot Function]

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