Human TCHP activation kit by CRISPRa
CAT#: GA113457
TCHP CRISPRa kit - CRISPR gene activation of human trichoplein keratin filament binding
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | TCHP |
Locus ID | 84260 |
Kit Components | GA113457G1, TCHP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113457G2, TCHP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113457G3, TCHP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001143852, NM_032300 |
Synonyms | TpMs |
Summary | Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN402566 | TCHP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |