Human TBC1D17 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TBC1D17
Locus ID	79735
Kit Components	GA112588G1, TBC1D17 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112588G2, TBC1D17 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112588G3, TBC1D17 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001168222, NM_024682
Synonyms	FLJ12168
Summary	Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.[UniProtKB/Swiss-Prot Function]

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