Human HMBOX1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HMBOX1
Locus ID	79618
Kit Components	GA112492G1, HMBOX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112492G2, HMBOX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112492G3, HMBOX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001135726, NM_024567, NM_001324382, NM_001324383, NM_001324384, NM_001324385, NM_001324386, NM_001324387, NM_001324388, NM_001324389, NM_001324390, NM_001324391, NM_001324392, NM_001324393, NM_001324394, NM_001324395, NM_001330498, NR_136757, NR_136758
Synonyms	HNF1LA; HOT1; PBHNF
Summary	Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).[UniProtKB/Swiss-Prot Function]

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