Human AICDA activation kit by CRISPRa
CAT#: GA111474
AICDA CRISPRa kit - CRISPR gene activation of human activation induced cytidine deaminase
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | AICDA |
Locus ID | 57379 |
Kit Components | GA111474G1, AICDA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111474G2, AICDA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111474G3, AICDA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001330343, NM_020661 |
Synonyms | AID; ARP2; CDA2; HEL-S-284; HIGM2 |
Summary | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN402949 | AICDA - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |