Human C12orf48 (PARPBP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PARPBP
Locus ID	55010
Kit Components	GA110449G1, C12orf48 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110449G2, C12orf48 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110449G3, C12orf48 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001319988, NM_001319993, NM_001319994, NM_001319995, NM_001319996, NM_017915, NR_135123
Synonyms	AROM; C12orf48; PARI
Summary	Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.[UniProtKB/Swiss-Prot Function]

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